Pyridine → HCID 57855892, compound

Participants

Reaction Steps

A solution of 6-Amino-5-methyl-2-trifluoromethyl-quinoline-7-carboxylic acid (0.60 g, 2.22 mmol), 2-(3-Chloro-pyridin-2-yl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (0.65 g 2.22 mmol) and pyridine (0.79 g, 9.992 mmol) in acetonitrile (30 ml) is cooled to 0-5° C. and treated drop wise with methane sulphonyl chloride (0.89 g, 7.77 mmol) dissolved in ca. 2 ml of acetonitrile. TLC analysis (4:1 hexane:ethyl acetate) after 2 hr shows reaction completion. The reaction mixture is concentrated to ca. 2/3 the original volume in vacuo and then poured onto 75 ml of ice/water. The resultant crystals are filtered at the pump, washed with water and dried in vacuo. This gives the title compound (1.0 g, 85.7%) as orange crystals.

Provenance & Evidence