Methylamine → HCID 57855977, compound

Participants

Reaction Steps

2-[2-(3-Chloro-pyridin-2-yl)-5-trifluoromethyl-2H-pyrazol-3-yl]-9-methyl-6-trifluoromethyl-3-oxa-1,5-diaza-anthracen-4-one (0.249, 0.456 mmol) in 20 ml of tetrahydrofurane is treated with methylamine (0.11 ml of 8M solution in ethanol, 0.9 mmol) and stirred at room temperature. TLC analysis (hexane:ethyl acetate 4:1) after 12 h shows reaction completion. The mixture is concentrated in vacuo, and then purified by flash column chromatography to give the title compound as white crystals.

Provenance & Evidence