HCID 57855889, compound → HCID 57855904, compound

HRID 2039640Notes

Reaction equation

HRID 2039640 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][C:13]=1[C:14]([OH:16])=[O:15])[N:10]=[C:9]([C:17]([F:20])([F:19])[F:18])[CH:8]=[CH:7]2)([O-])=O>C(O)C.[Ni]>[NH2:1][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][C:13]=1[C:14]([OH:16])=[O:15])[N:10]=[C:9]([C:17]([F:20])([F:18])[F:19])[CH:8]=[CH:7]2

Participants

4

Reactant 1

HCID 57855889HCID 57855889, compound

Product 1

HCID 57855904HCID 57855904, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

6-Nitro-2-trifluoromethyl-quinoline-7-carboxylic acid is hydrogenated in ethanol in the presence of Raney-Ni analogously to the procedure described for example H-18, step g). This gives the title product as yellow crystals. LC/MS: 257 (M+1)+.

Sources & evidence

ORD record
ord-42add4ecbbc24042913be690f2080a3b
Source dataset
uspto-grants-2013_11
Patent number
US08580785B2

Reaction notes

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