3-Bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid → HCID 57855895, compound

HRID 2039641Notes

Reaction equation

HRID 2039641 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[C:12]([OH:14])=[O:13])[N:8]=[C:7]([C:15]([F:18])([F:17])[F:16])[CH:6]=[CH:5]2.[Br:19][C:20]1[CH:21]=[C:22]([C:32](O)=O)[N:23]([C:25]2[C:30]([Cl:31])=[CH:29][CH:28]=[CH:27][N:26]=2)[N:24]=1>>[Br:19][C:20]1[CH:21]=[C:22]([C:32]2[O:13][C:12](=[O:14])[C:11]3[C:2](=[CH:3][C:4]4[C:9]([CH:10]=3)=[N:8][C:7]([C:15]([F:18])([F:16])[F:17])=[CH:6][CH:5]=4)[N:1]=2)[N:23]([C:25]2[C:30]([Cl:31])=[CH:29][CH:28]=[CH:27][N:26]=2)[N:24]=1

Participants

3

Reactant 2

HCID 115875353-Bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acidHCID 57855904HCID 57855904, compound

Product 1

HCID 57855895HCID 57855895, compound

Procedure

Prepared from 6-Amino-2-trifluoromethyl-quinoline-7-carboxylic acid and 5-Bromo-2-(3-chloro-pyridin-2-yl)-2H-pyrazole-3-carboxylic acid analogously to the procedure described in step h) of example H-18. This gives the title compound as orange crystals.

Sources & evidence

ORD record
ord-7a2daac687e84706a83ad127a792ea01
Source dataset
uspto-grants-2013_11
Patent number
US08580785B2

Reaction notes

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