N-chlorosuccinamide → HCID 131731039, compound

Participants

Reaction Conditions

Reaction Steps

6-Amino-2-trifluoromethyl-quinoline-7-carboxylic acid (0.50 g, 1.952 mmol is dissolved in dimethyl formamide (10 ml) and treated with N-chlorosuccinamide (0.26 g, 1.952 mmol) and the mixture warmed to 80° C. After 1 hr the reaction is complete as shown by LC/MS analysis. The reaction mixture is cooled, diluted with ethyl acetate, and then washed successively with water and brine. The organic phase is dried over sodium sulphate, filtered and the filtrate concentrated in vacuo. The residue was purified by flash chromatography eluting with eluting with a mixture of toluene, ethyl alcohol, dioxane, triethylamine and water (100:40:20:20:5 parts by volume) to give the title compound as a viscous oil.

Provenance & Evidence