HCID 23634344, compound → HCID 23633263, compound

HRID 2039675Notes

Reaction equation

HRID 2039675 reaction equation
[C:1]([C:5]1[N:10]=[CH:9][N:8]=[C:7]([NH:11][C:12]([NH:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][C:22]3[CH:27]=[CH:26][N:25]=[C:24]([C:28]#[N:29])[CH:23]=3)=[CH:17][C:16]=2F)=[O:13])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].NC1C=CC(OC2C=CN=C(C(=[S:45])N)C=2)=CC=1>>[C:1]([C:5]1[N:10]=[CH:9][N:8]=[C:7]([NH:11][C:12](=[O:13])[NH:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][C:22]3[CH:27]=[CH:26][N:25]=[C:24]([C:28](=[S:45])[NH2:29])[CH:23]=3)=[CH:17][CH:16]=2)[CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 23634344HCID 23634344, compoundHCID 86640577HCID 86640577, compound

Product 1

HCID 23633263HCID 23633263, compound

Procedure

The title compound was prepared in the same manner as described for 1-(6-tert-butylpyrimidin-4-yl)-3-[4-(2-cyanopyridin-4-yloxy)-2-fluorophenyl]urea, replacing 4-(4-amino-3-fluorophenoxy)pyridine-2-car-bonitrile for 4-(4-aminophenoxy)pyridine-2-thioamide. 1H-NMR (DMSO-d6) δ 10.32 (broad s, 1H), 10.20 (broad s, 1H), 10.13 (s, 1H), 9.93 (broad s, 1H), 9.72 (s, 1H), 8.74 (d, J=1.2 Hz, 1H), 8.46 (d, J=5.7 Hz, 1H), 7.95 (d, J=2.1 Hz, 1H), 7.67 (d, J=1.2 Hz, 1H), 7.64 to 7.60 (m, 2H), 7.21 to 7.17 (m, 2H), 7.12 (dd, J=5.7, 3.0 Hz, 1H), 1.26 (s, 9H); LC-MS m/z 423 [M+H]+, RT=3.39 min.

Sources & evidence

ORD record
ord-0834a92c746e44cba311fc29ea3f46a2
Source dataset
uspto-grants-2013_11
Patent number
US08580798B2

Reaction notes

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