Potassium Carbonate → HCID 58266274, compound

Participants

Reaction Steps

500 mg (1.164 mmol) of the compound from Example 5A were stirred together with 220 mg (1.397 mmol) of methyl bromoacetate and 322 mg (2.329 mmol) of potassium carbonate in 20 ml of DMF at 60° C. overnight. The solid was then filtered off, the filtrate was concentrated on a rotary evaporator, the residue was dissolved in dichloromethane and this solution was washed three times with water. The organic phase was separated off, dried over sodium sulphate, filtered and concentrated. The crude product was purified by chromatography on silica gel (mobile phase toluene/ethyl acetate 3:1). This gave 419 mg (72% of theory) of the desired product.

Provenance & Evidence