Bromine → HCID 58266282, compound

Participants

Reaction Steps

Ethyl 4-(4-cyanophenyl)-1-[4-fluoro-3-(trifluoromethyl)phenyl]-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (447 mg, 1.0 mmol) was dissolved in chloroform (10 ml) and bromine (176 mg, 1.10 mmol) was added at 0° C. The ice bath was removed and the mixture was stirred at room temperature for 0.5 h. The reaction mixture was then diluted with chloroform (20 ml) and washed successively with 10% strength aqueous sodium thiosulphate solution (10 ml) and concentrated aqueous sodium chloride solution (10 ml). The organic phase was separated off, dried over sodium sulphate, filtered and concentrated on a rotary evaporator. This gave 570 mg (quant.) of the target compound which was reacted further without further purification.

Provenance & Evidence