Methylhydrazine → HCID 58266267, compound

Participants

Reaction Conditions

Reaction Steps

527 mg (1.0 mmol) of ethyl 4-(4-cyanophenyl)-1-[4-fluoro-3-(trifluoromethyl)phenyl]-6-(bromomethyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate were dissolved in 25 ml of dioxane, and 138 mg (3.0 mmol; 3 eq.) of methylhydrazine were added. The mixture was stirred at 120° C. for 1 h and then concentrated. The residue was purified directly by preparative HPLC (column: Gromsil C-18 10 μm; mobile phase: acetonitrile/water+0.1% TFA 10:90→90:10). This gave 270 mg (55% of theory) of the target compound.

Provenance & Evidence