HuagongsheHuagongshe Chemistry Print Report · For research reference only
7H-Pyrrolo(2,3-d)pyrimidine, 4-chloro- → 7H-Pyrrolo(2,3-d)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7H-Pyrrolo(2,3-d)pyrimidine, 4-chloro- | HCID 5356682 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Palladium | HCID 23938 | — |
| Solvent | HCID 178418361 | HCID 178418361 | — |
| Product | 7H-Pyrrolo(2,3-d)pyrimidine | HCID 261591 | 99.1% |
Reaction Steps
As shown in FIG. 1—step i, 4-chloro-7H-pyrrolo[2,3-d]pyrimidine (compound 1001) (130 mg, 0.847 mmol) was dissolved in 3 mL of methanol and hydrogenated under 1 atm of hydrogen over Pd—C 10% for 16 hours. Concentration to dryness provided 100 mg (98%) of 7H-pyrrolo[2,3-d]pyrimidine [compound 1002, 1H-NMR (CD3OD): δ 9.4 (s, 1H); 9.1 (s, 1H); 7.9 (s, 1H); 7.1 (s, 1H)].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580802B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-63eb15bc607b4373812219835d2b6c55 |
| Source note | uspto-grants-2013_11 |