Aniline → HCID 86654843, compound

Participants

Reaction Steps

To a solution of 3-((5-benzoyl-7H-pyrrolo[2,3-d]pyrimidine-4-yl)amino)benzoic acid (25 mg, 0.07 mmol) in DMF (1 mL) was added DIPEA (18 μL, 0.105 mmol), HBTU (32 mg, 0.084 mmol), and aniline (7.6 μL, 0.084 mmol). The reaction was stirred at room temperature for 18 hours. The crude was purified by reverse phase preparative HPLC. M.p.>300° C.; 400 MHz 1HNMR (DMSO-d6) δ 13.04 (s, 1H), 11.50 (s, 1H), 10.34 (s, 1H), 8.50 (s, 1H), 8.33 (t, J=1.6 Hz, 1H), 8.26-8.23 (d, J=8.0 Hz, 1H), 7.99 (d, J=2.4 Hz, 1H), 7.88 (d, J=6.8 Hz, 2H), 7.79 (d, J=7.6 Hz, 1H), 7.69-7.53 (m, 5H), 7.37 (t, J=7.6 Hz, 2H), 7.11 (t, J=6.8 Hz, 1H); LCMS [M+H] 434.

Provenance & Evidence