Trifluoroacetic acid → HCID 53258567, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of tert-butyl(3-((5-benzoyl-7H-pyrrolo[2,3-d]pyrimidine-4-yl)amino)phenyl)carbamate (5.8 g, 13.5 mmol) in DCM (50 mL) was added 25 mL of TFA. The mixture was heated at 50° C. for 1 hour. Solvent was removed under reduced pressure. The residue was washed with DCM and dried on high vacuum to give an off-white solid. M.p.=280-282° C.; 400 MHz 1HNMR (DMSO-d6) δ 13.11 (s, 1H), 11.56 (s, 1H), 8.51 (s, 1H), 8.09 (s, 1H), 8.01 (s, 1H), 7.86 (d, J=7.6 Hz, 2H), 7.70 (t, J=10 Hz, 2H), 7.60 (t, J=7.2 Hz, 2H), 7.46 (t, J=8.0 Hz, 1H), 6.95 (d, J=7.2 Hz, 1H); LCMS [M+H] 330.

Provenance & Evidence