Trifluoroacetic acid → HCID 58327699, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of tert-butyl(4-((5-benzoyl-7H-pyrrolo[2,3-d]pyrimidine-4-yl)amino)benzyl)carbamate (0.18 g, 0.41 mmol) in DCM (1.5 mL) was added 0.5 mL of TFA. The mixture was heated at 50° C. for 1 hour. The solvent was removed under reduced pressure. The residue was washed with DCM and dried on high vacuum give a yellow solid. M.p.=255-257° C.; 400 MHz 1HNMR (DMSO-d6) δ 13.05 (s, 1H), 11.43 (s, 1H), 8.48 (s, 1H), 7.98-7.96 (m, 3H), 7.85 (d, J=8.4 Hz, 2H), 7.70 (t, J=7.6 Hz, 1H), 7.60 (t, J=7.6 Hz, 2H), 7.48 (d, J=8.4 Hz, 2H), 4.03 (q, J=5.2 Hz, 2H); LCMS [M+H] 344.

Provenance & Evidence