Hydrochloric Acid → HCID 71743116, compound

Participants

Reaction Conditions

Reaction Steps

In a microwaveable vessel, 1.03 g of N-(2,6-dichloropyridin-3-yl)-4-methoxy-3,5-dimethylbenzamide were dissolved in 15 ml of dry tetrahydrofuran, and 30 mg of copper(I) iodide, 57 mg of 1,10-phenanthroline and 1.54 g of cesium carbonate were added. In a microwave sunthesizer, the reaction mixture was then heated at 140° C. for 2 h. For work-up, the mixture was added to 10 ml of a 0.5 M aqueous hydrochloric acid solution. The mixture was extracted twice with ethyl acetate. The collected organic phases were combined and the solvent was removed under reduced pressure. This gave 0.88 g (98%) of the product, which was reacted further without any further purification.

Provenance & Evidence