3-(2-Bromoacetyl)benzonitrile → HCID 86646641, compound

Participants

Reaction Steps

A mixture of N-(adamantan-1-ylmethyl)-2-methylnicotinamide (300 mg, 1.05 mmol) and 3-(bromoacetyl)benzonitrile (235 mg, 1.05 mmol) in 10 mL of acetone is stirred at reflux for 2.5 days. After cooling to rt, most of the acetone is evaporated, and the remaining mixture is filtered. The collected solid is dried in vacuo to give the title compound as a white solid. 1H NMR (400 MHz, DMSO-d6) δ 8.93 (1H, m), 8.86 (1H, bs), 8.62 (1H, d), 8.58 (1H, s), 8.33 (1H, d), 8.26 (1H, d), 8.14 (1H, t), 7.87 (1H, t), 6.60 (2H, s), 3.01 (2H, d), 2.67 (3H, s), 1.94 (3H, s), 1.63 (6H, m), 1.51 (6H, s).

Provenance & Evidence