HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → Laquinimod Sodium
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | Laquinimod | HCID 54677946 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Laquinimod Sodium | HCID 23697158 | 92% |
Reaction Steps
Deuterated laquinimod prepared in Step 2 was suspended in ethanol and treated with 20% aqueous NaOH solution. The precipitated sodium salt was stirred for 3 hours, filtered and washed with ethanol. Drying in vacuum provided deuterated laquinimod sodium salt (92-94% yield). Identity and purity were proven by NMR, MS and HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580819B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-be770ba3f9854c2e9bbfef055591d70d |
| Source note | uspto-grants-2013_11 |