反应详情

Dissolve (R)-5-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-2-nitropropyl]-2,2-diphenylmorpholine-4-carboxylic acid tert-butyl ester (0.172 g, 0.31 mmol) in dry methanol (8 mL), add nickel chloride (0.060 g, 0.46 mmol) then sodium borohydride (0.059 g, 1.55 mmol). Stir 15 minutes, add water (˜2 mL) and concentrate. Add ethyl acetate (˜70 mL), filter (Celite®), wash with water and saturated aqueous sodium chloride. Dry (magnesium sulfate), filter and concentrate to give the desired compound as a white solid.

1. concentrationconcentrate
2. filtrationAdd ethyl acetate (˜70 mL), filter (Celite®)
3. washwash with water and saturated aqueous sodium chloride
4. dry with materialDry (magnesium sulfate)
5. filtrationfilter
6. concentrationconcentrate