Potassium Carbonate → HCID 86615507, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-benzyl-5-(3,5-bis-trifluoromethyl-benzyloxymethyl)-4-o-tolyl-1,2,3,6-tetrahydro-pyridine (76 mg, 0.15 mmol), potassium carbonate (20 mg, 0.15 mmol) and 1-chloroethyl chloroformate (23 mg, 0.16 mmol) in 3 ml of 1,2-dichloroethane was heated at 50° C. for 3 h. The mixture was filtered and concentrated in vacuo. The residue was dissolved in 2 ml of methanol and heated at reflux over night. Evaporation of the solvent in vacuo was followed by flash column chromatography to give the free base of the title compound. Dissolution in a 2 M solution of hydrochloric acid in diethyl ether and concentration in vacuo gave 57 mg (84%) of the title compound as a white solid.

Provenance & Evidence