6-hydroxy-5-methoxy-2,3-dihydro-1H-inden-1-one → 5-Hydroxy-6-methoxy-2,3-dihydro-1H-inden-1-one

HRID 2039813노트

반응식

HRID 2039813 반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][C:12]([O:14]CC)=O)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].OC1C=C2C(CCC2=O)=CC=1OC>>[OH:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:6][C:7]=1[O:8][CH3:9])[C:12](=[O:14])[CH2:11][CH2:10]2

참가 물질

3

반응물 2

HCID 2331486-hydroxy-5-methoxy-2,3-dihydro-1H-inden-1-oneHCID 69043564Ethyl 3-(3-hydroxy-4-methoxyphenyl)acrylate

생성물 1

HCID 147633955-Hydroxy-6-methoxy-2,3-dihydro-1H-inden-1-one

실험 절차

5-Hydroxy-6-methoxy-2,3-dihydro-1H-inden-1-one 18b was prepared from 35b according to the protocol described for the preparation of compound 18a in Example 33 (Scheme 11). Isolated as light brown powder in 67% overall yield (3.55 g). 1H NMR (300 MHz, CDCl3): δ 2.69 (2H, m); 3.03 (2H, m); 3.92 (3H, s); 4.28 (1H, broad s); 6.92 (1H, s); 7.17 (1H, s). 13C NMR (75 Hz, CDCl3): δ 24.65; 35.86; 55.05; 103.68; 111.00; 127.98; 147.67; 151.32; 153.72; 206.88.

후처리

  1. customIsolated as light brown powder in 67%
  2. customoverall yield (3.55 g)

출처 및 근거

ORD 기록
ord-7c36092ecd8a4994b71916a3b74c729a
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08580822B2

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