5-Fluoro-2-methylphenol → HCID 66922252, compound

HRID 2039832Notes

Reaction equation

HRID 2039832 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[C:24]3[C:19](=[N:20][CH:21]=[CH:22][CH:23]=3)[N:18]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[C:17]=2Cl)=[O:15])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[F:32][C:33]1[CH:34]=[CH:35][C:36]([CH3:40])=[C:37]([OH:39])[CH:38]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[C:24]3[C:19](=[N:20][CH:21]=[CH:22][CH:23]=3)[N:18]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[C:17]=2[O:39][C:37]2[CH:38]=[C:33]([F:32])[CH:34]=[CH:35][C:36]=2[CH3:40])=[O:15])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 27746165-Fluoro-2-methylphenolHCID 66922337HCID 66922337, compound

Product 1

HCID 66922252HCID 66922252, compound

Procedure

The title compound was prepared from the compound of step 6 (50.0 mg, 113 μmol) and 5-fluoro-2-methylphenol analogously as described in example 1, step 6, and purification by preparative HPLC. Yield: 28 mg.

Workup

  1. customas described in example 1, step 6, and purification by preparative HPLC

Sources & evidence

ORD record
ord-56a25aae9c704ca79a6eeef1562f49de
Source dataset
uspto-grants-2013_11
Patent number
US08580813B2

Reaction notes

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