5-Fluoro-2-methylphenol → 4-[2-(5-Fluoro-2-methyl-phenoxy)-6-methoxy-1-phenyl-1h-pyrrolo[3,2-c]pyridine-3-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester

HRID 2039839Notes

Reaction equation

HRID 2039839 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[C:20]3[CH:21]=[N:22][C:23]([O:25][CH3:26])=[CH:24][C:19]=3[N:18]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[C:17]=2Cl)=[O:15])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[F:34][C:35]1[CH:36]=[CH:37][C:38]([CH3:42])=[C:39]([OH:41])[CH:40]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[C:20]3[CH:21]=[N:22][C:23]([O:25][CH3:26])=[CH:24][C:19]=3[N:18]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[C:17]=2[O:41][C:39]2[CH:40]=[C:35]([F:34])[CH:36]=[CH:37][C:38]=2[CH3:42])=[O:15])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 27746165-Fluoro-2-methylphenolHCID 66922140HCID 66922140, compound

Product 1

HCID 669221784-[2-(5-Fluoro-2-methyl-phenoxy)-6-methoxy-1-phenyl-1h-pyrrolo[3,2-c]pyridine-3-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester

Procedure

The title compound was prepared analogously as described in example 1, step 6, from the compound of example 32, step 6, (100 mg, 212 μmol) and 5-fluoro-2-methylphenol.

Sources & evidence

ORD record
ord-6e1b3358608e40eb980949147491be27
Source dataset
uspto-grants-2013_11
Patent number
US08580813B2

Reaction notes

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