N-methyl-2-pyrrolidone → HCID 66922282, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of the compound of example 38, step 6, (65 mg, 115 μmol), iron(III) acetylacetonate (2.03 mg, 5.7 μmol) and NMP (102.6 mg, 1.04 mmol) in THF (5 ml) was cooled to 0° C. Ethylmagnesium chloride (115 μl, 230 μmol, 2 M in THF) was added and the resulting solution was stirred for 5 min. The brown mixture was quenched with water and extracted with EA. The organic layers were dried over sodium sulfate and concentrated. The residue was purified by silica gel chromatography (EA/HEP) to give 29 mg of the title compound.

Provenance & Evidence