Methyl 5-nitro-1H-pyrrolo[2,3-b]pyridine-2-carboxylate → Methyl 5-amino-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

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Reaction Steps

An autoclave is charged with 2.9 g (13.12 mmol) of methyl 5-nitro-1H-pyrrolo[2,3-b]pyridine-2-carboxylate (Azasynth), 290 mg of palladium on charcoal 10% and 200 mL of methanol. The reaction mixture is placed under 20 bar of hydrogen, and stirred for 18 h at room temperature. The solution is then filtered on Celite, and the Celite is rinsed with 3×100 mL of hot methanol. The filtrate is evaporated under reduced pressure. 2.38 g of a yellow solid is obtained at a yield of 95%.

Provenance & Evidence