Potassium Iodide → HCID 68760189, compound

Participants

Reaction Steps

A reactor is charged with 1 g (3.3 mmol) of the solid obtained in step 1, 2.28 g (16.5 mmol) of potassium carbonate, 30 ml of acetone, 0.39 g (3.96 mmol) of N-methylpiperazine and 55 mg (0.33 mmol) of potassium iodide. The mixture is heated at reflux for 6 hours. The solvent is then evaporated under reduce pressure and the residue is taken off into 100 ml of a saturated sodium bicarbonate solution. The aqueous phase is extracted by 3*30 ml ethyl acetate. The organic phases are then combined, dried on sodium sulphate and evaporated under reduced pressure. The obtained product is triturated in ethylic ester and then dried to give a white solid (700 mg, 56%).

Provenance & Evidence