Lithium borohydride → HCID 58564709, compound

Participants

Reaction Steps

A reactor is charged with 100 mg (0.26 mmol) of methyl 5-(4-((4-methylpiperazin-1-yl)methyl)benzamido)-2-methylbenzoate (example 82, step 2) in 5 ml anhydrous tetrahydrofuran and 38 mg (1.75 mmol) of lithium borohydride is added. The mixture is stirred at room temperature for 16 hours. The mixture is then concentrated under reduced pressure, taken off into 60 ml of ethyl acetate, washed with 20 ml of a saturated NaHCO3 solution, 20 ml of water and 20 ml of a saturated NaCl solution. The organic phase is dried, evaporated and the residue is taken off and triturated into ethylic ester to give a solid (80 mg, 86%)

Provenance & Evidence