反应详情

A reactor is charged with 1 g (4.9 mmol) of 3-(trifluoromethyl)-4-methylbenzoic acid in 10 ml methanol in the presence of a catalytic amount of sulphuric acid. The mixture is heated for 6 hours at reflux. The solvent is then evaporated under reduced pressure and 100 ml of a saturated sodium bicarbonate solution is added to the mixture. The solution is extracted by 3*30 ml ethyl acetate. The organic phases are combined, dried on sodium sulphate and evaporated under reduced pressure to give the expected product (1 g, 95%).

1. temperatureThe mixture is heated for 6 hours
2. temperatureat reflux
3. customThe solvent is then evaporated under reduced pressure and 100 ml of a saturated sodium bicarbonate solution
4. additionis added to the mixture
5. extractionThe solution is extracted by 3*30 ml ethyl acetate
6. customdried on sodium sulphate
7. customevaporated under reduced pressure