反应详情

A reactor is charged with 1 g (4.6 mmol) of the compound obtained in step 1, 0.97 g (5.5 mmol) of N-bromosuccinimide, 133 mg (0.55 mmol) of benzyl peroxide and 25 ml of carbon tetrachloride. The mixture is heated for 4 hours at reflux. The solvent is evaporated under reduced pressure and 100 ml of a saturated sodium bicarbonate solution is added. The solution obtained is extracted with 3*30 ml ethyl acetate. The organic phases are combined, dried on sodium sulphate and evaporated under reduced pressure to give the expected product (1.2 g, 88%).

1. temperatureThe mixture is heated for 4 hours
2. temperatureat reflux
3. customThe solvent is evaporated under reduced pressure and 100 ml of a saturated sodium bicarbonate solution
4. additionis added
5. customThe solution obtained
6. extractionis extracted with 3*30 ml ethyl acetate
7. customdried on sodium sulphate
8. customevaporated under reduced pressure