HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Benzyl (R)-2-amino-3-(2-benzyloxycarbonylaminoethylsulfanyl)propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Benzyl(R)-3-(2-benzyloxycarbonylaminoethylsulfanyl)-2-tert-butoxycarbonylaminopropionate | HCID 58360509 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Benzyl (R)-2-amino-3-(2-benzyloxycarbonylaminoethylsulfanyl)propionate | HCID 58360484 | — |
Reaction Steps
A solution of 0.50 g (1.023 mmol) of benzyl (R)-3-(2-benzyloxycarbonylaminoethyl-sulfanyl)-2-tert-butoxycarbonylaminopropionate in 5 ml of dichloromethane was mixed with the same volume of trifluoroacetic acid and left to stand at RT for 1 h. It was then concentrated and directly reacted further.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580777B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-0c415156730d430680850cb702c76365 |
| Source note | uspto-grants-2013_11 |