p-Toluenesulfonic acid → HCID 56849174, compound

Participants

Reaction Conditions

Reaction Steps

R105 (65.0 mg, 0.114 mmol) is treated with ethanol (1.5 mL) and p-toluenesulfonic acid (5.7 mg, 0.20 mmol) and the resulting mixture is stirred at 60° C. for 2.5 hours. The reaction was cooled to room temperature and filtered. The resulting solid was purified by reverse-phase preparative HPLC eluting 10-90% acetonitrile/water/0.1% formic acid to give Example 239 (22.0 mg); m/z 487.4 [M+1].

Provenance & Evidence