5-(4-Iodo-3-methylphenyl)-2-methyloxazole-4-carboxylic acid → N-(2-((4-(1,1-Difluoroethyl)oxazol-2-yl)methyl)-2H-1,2,3-triazol-4-yl)-5-(4-iodo-3-methylphenyl)-2-methyloxazole-4-carboxamide

HRID 2040055Notes

Reaction equation

HRID 2040055 reaction equation
[F:1][C:2]([C:5]1[N:6]=[C:7]([CH2:10][N:11]2[N:15]=[C:14]([NH2:16])[CH:13]=[N:12]2)[O:8][CH:9]=1)([F:4])[CH3:3].[I:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[O:28][C:27]([CH3:29])=[N:26][C:25]=2[C:30](O)=[O:31])=[CH:20][C:19]=1[CH3:33]>>[F:1][C:2]([C:5]1[N:6]=[C:7]([CH2:10][N:11]2[N:15]=[C:14]([NH:16][C:30]([C:25]3[N:26]=[C:27]([CH3:29])[O:28][C:24]=3[C:21]3[CH:22]=[CH:23][C:18]([I:17])=[C:19]([CH3:33])[CH:20]=3)=[O:31])[CH:13]=[N:12]2)[O:8][CH:9]=1)([F:4])[CH3:3]

Participants

3

Reactant 2

HCID 671278685-(4-Iodo-3-methylphenyl)-2-methyloxazole-4-carboxylic acidHCID 671278932-[4-(1,1-Difluoro-ethyl)-oxazol-2-ylmethyl]-2H-[1,2,3]triazol-4-ylamine

Product 1

HCID 67288310N-(2-((4-(1,1-Difluoroethyl)oxazol-2-yl)methyl)-2H-1,2,3-triazol-4-yl)-5-(4-iodo-3-methylphenyl)-2-methyloxazole-4-carboxamide

Procedure

Following general procedure A, starting from 2-((4-(1,1-difluoroethyl)oxazol-2-yl)methyl)-2H-1,2,3-triazol-4-amine and 5-(4-iodo-3-methylphenyl)-2-methyloxazole-4-carboxylic acid. LC-MS-conditions 07: tR=1.03 min; [M+H]+=555.03.

Sources & evidence

ORD record
ord-2fd26a2ab3a14d71a7cad2dc8a8500b9
Source dataset
uspto-grants-2013_11
Patent number
US08580831B2

Reaction notes

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