1-(2-((4-Amino-2H-1,2,3-triazol-2-yl)methyl)thiazol-4-yl)ethanone → N-(2-((4-Acetylthiazol-2-yl)methyl)-2H-1,2,3-triazol-4-yl)-5-(4-iodo-3-methylphenyl)-2-methyloxazole-4-carboxamide

HRID 2040056Notes

Reaction equation

HRID 2040056 reaction equation
[NH2:1][C:2]1[CH:6]=[N:5][N:4]([CH2:7][C:8]2[S:9][CH:10]=[C:11]([C:13](=[O:15])[CH3:14])[N:12]=2)[N:3]=1.[I:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[O:27][C:26]([CH3:28])=[N:25][C:24]=2[C:29](O)=[O:30])=[CH:19][C:18]=1[CH3:32]>>[C:13]([C:11]1[N:12]=[C:8]([CH2:7][N:4]2[N:3]=[C:2]([NH:1][C:29]([C:24]3[N:25]=[C:26]([CH3:28])[O:27][C:23]=3[C:20]3[CH:21]=[CH:22][C:17]([I:16])=[C:18]([CH3:32])[CH:19]=3)=[O:30])[CH:6]=[N:5]2)[S:9][CH:10]=1)(=[O:15])[CH3:14]

Participants

3

Reactant 2

HCID 671278651-(2-((4-Amino-2H-1,2,3-triazol-2-yl)methyl)thiazol-4-yl)ethanoneHCID 671278685-(4-Iodo-3-methylphenyl)-2-methyloxazole-4-carboxylic acid

Product 1

HCID 67287415N-(2-((4-Acetylthiazol-2-yl)methyl)-2H-1,2,3-triazol-4-yl)-5-(4-iodo-3-methylphenyl)-2-methyloxazole-4-carboxamide

Procedure

Following general procedure A, starting from 1-(2-((4-amino-2H-1,2,3-triazol-2-yl)methyl)thiazol-4-yl)ethanone and 5-(4-iodo-3-methylphenyl)-2-methyloxazole-4-carboxylic acid. LC-MS-conditions 02: tR=1.12 min; [M+H]+=549.20.

Sources & evidence

ORD record
ord-e3cacdc47a524949b6efe0fcb154d234
Source dataset
uspto-grants-2013_11
Patent number
US08580831B2

Reaction notes

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