HuagongsheHuagongshe Chemistry Print Report · For research reference only
4(5H)-Thiazolone, 2-amino- → 4-[4-(2-Amino-4-oxo-4H-thiazol-5-ylidenemethyl)-2-methoxy-phenoxy]-3-trifluoromethyl-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4(5H)-Thiazolone, 2-amino- | HCID 11175 | — |
| Reactant | 4-(4-Formyl-2-methoxyphenoxy)-3-(trifluoromethyl)benzonitrile | HCID 51051507 | — |
| Product | 4-[4-(2-Amino-4-oxo-4H-thiazol-5-ylidenemethyl)-2-methoxy-phenoxy]-3-trifluoromethyl-benzonitrile | HCID 69046963 | — |
Reaction Steps
4-[4-(2-Amino-4-oxo-4H-thiazol-5-ylidenemethyl)-2-methoxy-phenoxy]-3-trifluoromethyl-benzonitrile was prepared using 2-amino-thiazol-4-one and 4-(4-Formyl-2-methoxy-phenoxy)-3-trifluoromethyl-benzonitrile according to General Procedure B. 1H NMR (400 Hz, DMSO-d6) δ 8.96 (bs, NH), 8.74 (bs, NH), 8.32 (d, 1H), 7.99 (dd, 1H), 7.65 (d, 1H), 7.47 (d, 1H), 7.36 (d, 1H), 7.24 (d, 1H), 6.89 (d, 1H), 3.88 (s, 3H); LC/MS (m/z) [M+1]+420.0 (C19H13F3N3O3S, 420.38).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580832B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-7301d0374fdd43a6a664e09f9225d311 |
| Source note | uspto-grants-2013_11 |