HuagongsheHuagongshe Chemistry Print Report · For research reference only
4(5H)-Thiazolone, 2-amino- → 4-[4-(2-Amino-4-oxo-4H-thiazol-5-ylidenemethyl)-2-methoxy-phenoxy]-3-chloro-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4(5H)-Thiazolone, 2-amino- | HCID 11175 | — |
| Reactant | 4-(2-Chloro-4-cyanophenoxy)-3-methoxybenzaldehyde | HCID 51051501 | — |
| Product | 4-[4-(2-Amino-4-oxo-4H-thiazol-5-ylidenemethyl)-2-methoxy-phenoxy]-3-chloro-benzonitrile | HCID 69272885 | — |
Reaction Steps
4-[4-(2-Amino-4-oxo-4H-thiazol-5-ylidenemethyl)-2-methoxy-phenoxy]-3-chloro-benzonitrile was prepared using 2-amino-thiazol-4-one and 4-(2-Chloro-4-cyanophenoxy)-3-methoxybenzaldehyde according to General Procedure B. 1H NMR (400 Hz, DMSO-d6) δ 9.47 (bs, NH), 9.21 (bs, NH), 8.17 (d, 1H), 7.70 (dd, 1H), 7.64 (s, 1H), 7.46 (d, 1H), 7.32 (d, 1H), 7.23 (dd, 1H), 6.81 (d, 1H), 3.79 (s, 3H); LC/MS (m/z) [M+1]+386.0 (calculated for C18H13ClN3O3S, 386.82).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580832B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-af827a14cd8f4d3a8cdc9c36fc33bfd7 |
| Source note | uspto-grants-2013_11 |