Rhodanine → HCID 86623143, compound

HRID 2040104Notes

Reaction equation

[S:1]1[CH2:7][C:5](=[O:6])[NH:4][C:2]1=[S:3].[F:8][C:9]1[CH:27]=[C:26]([CH:28]=O)[CH:25]=[CH:24][C:10]=1[O:11][C:12]1[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[CH:14][C:13]=1[C:20]([F:23])([F:22])[F:21]>>[F:8][C:9]1[CH:27]=[C:26]([CH:28]=[C:7]2[S:1][C:2](=[S:3])[NH:4][C:5]2=[O:6])[CH:25]=[CH:24][C:10]=1[O:11][C:12]1[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[CH:14][C:13]=1[C:20]([F:21])([F:22])[F:23]

Participants

Reactant 2

HCID 1201546Rhodanine

HCID 86623144HCID 86623144, compound

Product 1

HCID 86623143HCID 86623143, compound

Procedure

4-[2-Fluoro-4-(4-oxo-2-thioxo-thiazolidin-5-ylidenemethyl)-phenoxy]-3-trifluoromethyl-benzonitrile was prepared using rhodanine and 4-(2-Fluoro-4-formyl-phenoxy)-3-trifluoromethyl-benzonitrile according the General Procedure B. 1H NMR (400 Hz, DMSO-d6) δ 8.41 (d, 1H), 8.11 (dd, 1H), 7.76 (d, 1H), 7.67 (s, 1H), 7.51 (m, 2H), 7.23 (d, 1H).

Sources & evidence

ORD record: ord-61e570885636480e9700a93f509be14e
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08580832B2

Reaction notes

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