tert-Butyl 2-(aminomethyl)morpholine-4-carboxylate → HCID 178489243, compound

HRID 2040106Notes

Reaction equation

HRID 2040106 reaction equation
[CH3:1][O:2][C:3]1[CH:21]=[C:20]([CH:22]=[C:23]2[S:27][C:26](SC)=[N:25][C:24]2=[O:30])[CH:19]=[CH:18][C:4]=1[O:5][C:6]1[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[CH:8][C:7]=1[C:14]([F:17])([F:16])[F:15].[C:31]([O:35][C:36]([N:38]1[CH2:43][CH2:42][O:41][CH:40]([CH2:44][NH2:45])[CH2:39]1)=[O:37])([CH3:34])([CH3:33])[CH3:32]>>[C:31]([O:35][C:36]([N:38]1[CH2:43][CH2:42][O:41][CH:40]([CH2:44][NH:45][C:26]2[S:27][C:23](=[CH:22][C:20]3[CH:19]=[CH:18][C:4]([O:5][C:6]4[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[CH:8][C:7]=4[C:14]([F:17])([F:15])[F:16])=[C:3]([O:2][CH3:1])[CH:21]=3)[C:24](=[O:30])[N:25]=2)[CH2:39]1)=[O:37])([CH3:34])([CH3:33])[CH3:32]

Participants

3

Reactant 2

HCID 19081094tert-Butyl 2-(aminomethyl)morpholine-4-carboxylateHCID 69041534HCID 69041534, compound

Product 1

HCID 178489243HCID 178489243, compound

Procedure

2-({5-[4-(4-Cyano-2-trifluoromethyl-phenoxy)-3-methoxy-benzylidene]-4-oxo-4,5-dihydro-thiazol-2-ylamino}-methyl)-morpholine-4-carboxylic acid tert-butyl ester was prepared using 4-[2-Methoxy-4-(2-methylsulfanyl-4-oxo-4H-thiazol-5-ylidenemethyl)-phenoxy]-3-trifluoromethyl-benzonitrile and 2-aminomethyl-morpholine-4-carboxylic acid tert-butyl ester as described in Example 5C.

Sources & evidence

ORD record
ord-06f2aaec476f4f659b0277811f2d8e18
Source dataset
uspto-grants-2013_11
Patent number
US08580832B2

Reaction notes

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