HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2040155Generated: October 27, 2026
Potassium Carbonate → 8-(4-Chlorophenyl)spiro[4.5]dec-8-ene-9-carbaldehyde
https://huagongshe.com/reaction/2040155
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Tetrabutylammonium | HCID 16028 | — |
| Reactant | 4-Chlorophenylboronic acid | HCID 74299 | — |
| Reactant | 8-Chlorospiro[4.5]dec-7-ene-7-carbaldehyde | HCID 86648176 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Water | HCID 962 | — |
| Product | 8-(4-Chlorophenyl)spiro[4.5]dec-8-ene-9-carbaldehyde | HCID 87295006 | — |
Reaction Steps
To a suspension of EXAMPLE 71A (3 g) in water (50 mL) was added 4-chlorophenylboronic acid (2.83 g), tetrabutylammonium (4.87 g), potassium carbonate (6.26 g) and palladium(II) acetate (0.169 g). The reaction mixture was stirred at 45° C. for 5 hours and extracted with dichloromethane. The organic layer was concentrated and the residue was loaded onto a silica gel column, and eluted with 5-20% ethyl acetate in hexane to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08580794B2 |
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| Source dataset | uspto-grants-2013_11 |
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| ORD ID | ord-b68128ca9e404dcb82f21801aa9ab04d |
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| Source note | uspto-grants-2013_11 |
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