tert-Butyl piperazine-1-carboxylate → HCID 86648177, compound

HRID 2040179Notes

Reaction equation

HRID 2040179 reaction equation
ClC1C=CC(C2[C:9]([CH:14]=[O:15])=[CH:10][CH:11]=[CH:12][CH:13]=2)=CC=1.[NH:16]1[CH2:20][CH2:19][C@@H:18]([NH:21][C:22](=[O:28])[O:23][C:24]([CH3:27])([CH3:26])[CH3:25])[CH2:17]1.N1(C(OC(C)(C)C)=O)CCNC[CH2:30]1>>[CH3:30][C:12]1([CH3:13])[CH2:11][CH:10]([N:16]2[CH2:20][CH2:19][C@@H:18]([NH:21][C:22](=[O:28])[O:23][C:24]([CH3:25])([CH3:27])[CH3:26])[CH2:17]2)[CH2:9][CH2:14][O:15]1

Participants

4

Reactant 3

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 13936894'-Chlorobiphenyl-2-carbaldehydeHCID 1514397(3R)-(+)-3-(tert-Butoxycarbonylamino)pyrrolidine

Product 1

HCID 86648177HCID 86648177, compound

Procedure

The title compound was prepared by substituting 2,2-dimethyldihydro-2H-pyran-4(3H)-one for 4′-chlorobiphenyl-2-carboxaldehyde and (R)-tert-butyl pyrrolidin-3-ylcarbamate for tert-butyl piperazine-1-carboxylate in EXAMPLE 1A.

Sources & evidence

ORD record
ord-1c9732249afc49da962264ad956bc8d7
Source dataset
uspto-grants-2013_11
Patent number
US08580794B2

Reaction notes

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