tert-Butyl piperazine-1-carboxylate → (S)-tert-Butyl 1-(oxetan-3-yl)pyrrolidin-3-ylcarbamate

HRID 2040217Notes

Reaction equation

HRID 2040217 reaction equation
[N:1]1([C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[O:14]1[CH2:17][C:16](=O)[CH2:15]1.ClC1C=CC(C2C(C=O)=CC=CC=2)=CC=1>>[O:14]1[CH2:17][CH:16]([N:4]2[CH2:3][CH2:2][C@H:6]([NH:1][C:7](=[O:8])[O:9][C:10]([CH3:11])([CH3:12])[CH3:13])[CH2:5]2)[CH2:15]1

Participants

4

Reactant 3

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 13936894'-Chlorobiphenyl-2-carbaldehydeHCID 150242543-Oxetanone

Product 1

HCID 56604508(S)-tert-Butyl 1-(oxetan-3-yl)pyrrolidin-3-ylcarbamate

Procedure

The title compound was prepared by substituting (S)-tert-butyl pyrrolidin-3-ylcarbamate for tert-butyl piperazine-1-carboxylate and 3-oxetanone for 4′-chlorobiphenyl-2-carboxaldehyde in EXAMPLE 1A.

Sources & evidence

ORD record
ord-495660d510254533990be834bfe2d4b4
Source dataset
uspto-grants-2013_11
Patent number
US08580794B2

Reaction notes

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