Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 1-Bromo-3,6-dioxaheptane | HCID 123532 | — |
| Reactant | HCID 67126429 | HCID 67126429 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 67170312 | HCID 67170312 | — |
Reaction Steps
To a solution of (R)-3-nitro-4-(pyrrolidin-3-ylamino)benzenesulfonamide (440 mg) in N,N-dimethylformamide (10 mL) was added sodium carbonate (132 mg) and 1-bromo-2-(2-methoxyethoxy)ethane (0.155 mL). The reaction mixture was heated at 60° C. for 18 hours and after an aqueous workup, the crude product was purified on silica gel with a 2.5-10% methanol in methylene chloride gradient to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08580794B2 |
|---|
| Source dataset | uspto-grants-2013_11 |
|---|
| ORD ID | ord-68bb650c1f7f4b9a93428e7d8b3dae8c |
|---|
| Source note | uspto-grants-2013_11 |
|---|
