Acetic Acid → Benzyl 9-oxo-3-azaspiro(5.5)undec-7-ene-3-carboxylate

HRID 2040241Notes

Reaction equation

HRID 2040241 reaction equation
N1([CH:7]=[C:8]2[CH2:13][CH2:12][N:11]([C:14]([O:16][CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[O:15])[CH2:10][CH2:9]2)CCCCC1.[CH3:24][C:25](=[O:28])[CH:26]=[CH2:27].C(O)(=O)C>C(O)C>[O:28]=[C:25]1[CH2:24][CH2:7][C:8]2([CH2:9][CH2:10][N:11]([C:14]([O:16][CH2:17][C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=3)=[O:15])[CH2:12][CH2:13]2)[CH:27]=[CH:26]1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 6570Methyl vinyl ketoneHCID 86642880Benzyl 4-(piperidin-1-ylmethylene)piperidine-1-carboxylate

Product 1

HCID 23435732Benzyl 9-oxo-3-azaspiro(5.5)undec-7-ene-3-carboxylate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of EXAMPLE 265A (15.88 g) in ethanol (300 mL) was added but-3-enone (3.89 g). The mixture was stirred at reflux overnight. Then acetic acid (30 mL) was added to the mixture which was stirred at reflux again overnight. The mixture was then concentrated under vacuum and the residue was diluted with ethyl acetate (400 mL) and washed with water and brine and dried over Na2SO4. After filtration and evaporation of the solvent, column purification gave the title compound.

Workup

  1. temperatureat reflux overnight
  2. stirringwas stirred
  3. temperatureat reflux again overnight
  4. concentrationThe mixture was then concentrated under vacuum
  5. additionthe residue was diluted with ethyl acetate (400 mL)
  6. washwashed with water and brine
  7. dry with materialdried over Na2SO4
  8. filtrationAfter filtration and evaporation of the solvent, column purification

Sources & evidence

ORD record
ord-9e21046569454b68a6edc312d31b1eee
Source dataset
uspto-grants-2013_11
Patent number
US08580794B2

Reaction notes

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