HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → [4-[Cyclopropyl(oxetan-3-yl)amino]cyclohexyl]methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | Ethyl 4-[cyclopropyl(oxetan-3-yl)amino]cyclohexane-1-carboxylate | HCID 67126835 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | [4-[Cyclopropyl(oxetan-3-yl)amino]cyclohexyl]methanol | HCID 67126731 | — |
Reaction Steps
To a solution of EXAMPLE 329B (1.2 g) in tetrahydrofuran (20 mL) was added lithium aluminum hydride (0.681 g). The mixture was stirred overnight. 2N aqueous NaOH solution was added dropwise to the reaction mixture. The mixture was then diluted with ethyl acetate (300 mL) and washed with water, brine and dried over Na2SO4. Filtration and evaporation of the solvent gave the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580794B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-70b55747e969416483f8238c93c61258 |
| Source note | uspto-grants-2013_11 |