HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-(Benzyloxymethyl)-1-oxa-3-azaspiro[4.5]decan-2-one → 8-(Hydroxymethyl)-1-oxa-3-azaspiro[4.5]decan-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-(Benzyloxymethyl)-1-oxa-3-azaspiro[4.5]decan-2-one | HCID 67126750 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 8-(Hydroxymethyl)-1-oxa-3-azaspiro[4.5]decan-2-one | HCID 57576531 | — |
Reaction Steps
A solution of EXAMPLE 385B (500 mg) in ethanol was added to wet 20% palladium hydroxide on carbon (2500 mg) in a 50 ml pressure bottle. The mixture was stirred at ambient temperature for 3 hours under hydrogen at 30 psi. The mixture was filtered and concentrated to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580794B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-98735a45df8b4764913e432d977be740 |
| Source note | uspto-grants-2013_11 |