HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Cyclohexanecarboxylic acid, 4-(hydroxymethyl)-, methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Cyclohexanecarboxylic acid, 4-(hydroxymethyl)- | HCID 202819 | — |
| Product | Cyclohexanecarboxylic acid, 4-(hydroxymethyl)-, methyl ester | HCID 11073869 | — |
Reaction Steps
To a cooled (0° C.) solution of 4-(hydroxymethyl)cyclohexanecarboxylic acid (40 g) in methanol (632 mL) was added thionyl chloride (22.15 mL) dropwise via an addition funnel. The reaction was slowly warmed to room temperature, stirred for 1 hour, concentrated by rotary evaporation, and the residue was purified by regular phase flash column chromatography (Analogix, 0-100% hexanes/ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580794B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-c46883042047485c98e065f7ad24955b |
| Source note | uspto-grants-2013_11 |