HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Methoxymethoxy)-1-phenylethanone → 5-(2,5-Difluorophenyl)-2-((methoxymethoxy)methyl)-2-phenyl-2,3-dihydro-1,3,4-thiadiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Methoxymethoxy)-1-phenylethanone | HCID 10511571 | — |
| Reactant | Benzenecarbothioic acid, 2,5-difluoro-, hydrazide | HCID 55279024 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | 5-(2,5-Difluorophenyl)-2-((methoxymethoxy)methyl)-2-phenyl-2,3-dihydro-1,3,4-thiadiazole | HCID 67214899 | 63% |
Reaction Steps
To a solution of 2-(methoxymethoxy)-1-phenylethanone (600 mg, 3.33 mmol) in ethanol/dichloromethane (12 mL, 3:1) was added 2,5-difluorobenzothiohydrazide (627 mg, 3.33 mmol). After stirring at room temperature for 16 hours, the mixture was concentrated under reduced pressure and chromatographed (9:1 hexanes/ethyl acetate) to afford the product (734 mg, 63%) as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580828B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-c8fafdd221894667aec98fba26b17a53 |
| Source note | uspto-grants-2013_11 |