反应详情

温度

0 °C

1.8 g (6 mmol) of the intermediate from Step C were dissolved in 20 ml pyridine. At 0° C. 0.99 g (6.3 mmol) phenyl chloroformate were added and afterwards the reaction mixture was stirred for 1 h at 0° C. This mixture was poured into an ice/water mixture. The pH of the aqueous phase was adjusted to 5 and the resulting mixture was extracted with ethyl acetate. The organic phase was separated, dried over magnesium sulfate and the solvent was removed in vacuo. The resulting solid (2 g) was used in the next step without further purification.

1. customAt 0° C
2. extractionthe resulting mixture was extracted with ethyl acetate
3. customThe organic phase was separated
4. dry with materialdried over magnesium sulfate
5. customthe solvent was removed in vacuo
6. customThe resulting solid (2 g) was used in the next step without further purification