huagongshe.com
HRID2040680

反应详情

EQUATION

反应方程式

HRID 2040680 的结构方程式

REACTANTS

反应物

1
结构：CCN(C[C@H]1C[C@@H](n2ccc3c(NCc4ccc(OC)cc4OC)ncnc32)[C@@H]2OC(C)(C)O[C@H]12)C1CC(CCC(=O)Nc2ccc(C(C)(C)C)cc2N)C1
HCID67775191

未命名化合物

PRODUCTS

生成物

1
结构：CCN(C[C@H]1C[C@@H](n2ccc3c(NCc4ccc(OC)cc4OC)ncnc32)[C@@H]2OC(C)(C)O[C@H]12)C1CC(CCc2nc3cc(C(C)(C)C)ccc3[nH]2)C1
HCID178464371

未命名化合物

收率 96.2%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(=O)O
溶剂HCID176

Acetic Acid

C2H4O2

PROCEDURE

实验过程

A solution of N-(2-amino-4-(tert-butyl)phenyl)-3-(3-((((3aR,4R,6R,6aS)-6-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)(ethyl)amino)cyclobutyl)propanamide (0.88 g, 1.2 mmol) in Acetic acid (3 mL) was stirred overnight at 60° C., the volatiles removed in vacuo and remaining residue purified by flash chromatography (DCM/7N NH3 in MeOH 93:7) to give the desired compound (0.85 g) as a foam.

WORKUP

后处理

  1. customthe volatiles removed in vacuo
  2. custompurified by flash chromatography (DCM/7N NH3 in MeOH 93:7)