HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2040753Generated: October 31, 2026
Water → (R)-1-(2-Methoxy-4-nitrophenyl)pyrrolidin-3-ol
https://huagongshe.com/reaction/2040753
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-Chloro-5-nitroanisole | HCID 70519 | — |
| Reactant | 4-Hydroxypyrrolidine | HCID 98210 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | Sodium chloride; water | HCID 57417360 | — |
| Product | (R)-1-(2-Methoxy-4-nitrophenyl)pyrrolidin-3-ol | HCID 15965522 | 82% |
Reaction Steps
A mixture of 2-chloro-5-nitroanisole (0.59 g, 3.1 mmol) and 3-hydroxy pyrrolidine (0.55 g, 6.2 mmol) was heated neat to 110° C. over night. Reaction mass was diluted with ethyl acetate and the organic layer was given water and brine wash, dried over Na2SO4, concentration yields dark red solid (0.6 g, 82% yield). LC-MS, [M+H]+=239.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08580959B2 |
|---|
| Source dataset | uspto-grants-2013_11 |
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| ORD ID | ord-5b429d0e2a9445a78067798b76c7b9b2 |
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| Source note | uspto-grants-2013_11 |
|---|
