HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-6-isobutylisonicotinic acid tert-butyl ester → 2-Chloro-6-isobutylisonicotinic acid hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-6-isobutylisonicotinic acid tert-butyl ester | HCID 86639876 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-Chloro-6-isobutylisonicotinic acid hydrochloride | HCID 86639877 | 102.8% |
Reaction Steps
A solution of 2-chloro-6-isobutylisonicotinic acid tert.-butyl ester (1.70 g, 6.3 mmol) in 4 N HCl in dioxane (50 mL) is stirred at 60° C. for 30 h. The solvent is evaporated and the crude product is purified by MPLC on silica gel (heptane:EA gradient) to give 2-chloro-6-isobutylisonicotinic acid hydrochloride (0.81 g) as a beige resin; LC-MS: tR=0.89 min, [M+1]+=214.02.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580824B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-b7cf0f4dde5b4adc993604e3630d18c3 |
| Source note | uspto-grants-2013_11 |