HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2040783Generated: October 31, 2026
Methanol → Methyl 2-chloro-6-methoxyisonicotinate
https://huagongshe.com/reaction/2040783
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 2-Chloro-6-methoxypyridine-4-carboxylic acid | HCID 2782124 | — |
| Solvent | Sulfuric Acid | HCID 1118 | — |
| Product | Methyl 2-chloro-6-methoxyisonicotinate | HCID 13339618 | — |
Reaction Steps
To a suspension of 2-chloro-6-methoxy-isonicotinic acid (2.00 g, 10.7 mmol) in MeOH (100 mL), H2SO4 (2 mL) is added. The mixture is stirred at 65° C. for 20 h. The solution is cooled to rt. A precipitate forms. The solid material is collected, washed with MeOH and dried to give 2-chloro-6-methoxy-isonicotinic acid methyl ester (1.66 g) as a white solid; LC-MS: tR=1.29 min; [M+1]+=202.00.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08580824B2 |
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| Source dataset | uspto-grants-2013_11 |
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| ORD ID | ord-9fa5ed80c47248ea80550dc27158facd |
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| Source note | uspto-grants-2013_11 |
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