4-Hydroxy-3-methoxybenzonitrile → HCID 178458443, compound

HRID 2040791Notes

Reaction equation

HRID 2040791 reaction equation
[CH2:1]([O:4][C:5]1[C:14](C)=[CH:13][C:8]([C:9]([NH:11][OH:12])=[NH:10])=[CH:7][C:6]=1C)[CH:2]=[CH2:3].[OH:17][C:18]1C=CC(C#N)=CC=1OC>>[CH2:1]([O:4][C:5]1[CH:14]=[CH:13][C:8]([C:9]([NH:11][OH:12])=[NH:10])=[CH:7][C:6]=1[O:17][CH3:18])[CH:2]=[CH2:3]

Participants

3

Reactant 2

HCID 781354-Hydroxy-3-methoxybenzonitrileHCID 178458380HCID 178458380, compound

Product 1

HCID 178458443HCID 178458443, compound

Procedure

The title compound is prepared in analogy to 4-allyloxy-N-hydroxy-3,5-dimethyl-benzamidine by allylating commercially available 4-hydroxy-3-methoxy-benzonitrile followed by transforming the nitrile to the hydroxyamidine; LC-MS: tR=0.59 min, [M+1]+=223.18.

Sources & evidence

ORD record
ord-a7db827ce14b49adaade683e8162e958
Source dataset
uspto-grants-2013_11
Patent number
US08580824B2

Reaction notes

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